Creation of the Regenerative Bioscience Center — RBC
Dr. Steven Stice and other faculty at the University of Georgia helped establish the Regenerative Bioscience Center (RBC). The goal, to lay a foundation for collaborative research, training and resource sharing.
Awarded host, only 1 of 5 Research Centers in the USA for NIH (HEST) Training
Funding Institution: National Heart, Lung, and Blood Institute. Workshop: Human Embryonic Stem Cell Toolbox (HEST). Awarded one million dollars to conduct a short course in human embryonic stem cell culture techniques twice a year. (HEST) brings together scientists with a particular training in embryology, developmental biology, tissue engineering, and cell biology to learn the intricate details, the "how to" and theory of hES cells self renewal.
Fracture Putty Discovery: $1.4 million to Conduct Large Animal Research from Baylor Medical School via a Contract from DARPA.
To start the bone regeneration process, the RBC used adult stem cells that produce a protein involved in bone healing and generation. They then incorporated them into a gel, combining the healing properties better known as "fracture putty." Broken bones in humans and animals are painful and often take months to heal. Complex fractures are a major cause of amputation of limbs for U.S. military men and women. This discovery may allow them to be up and moving as fast as days (not weeks) afterward.
New Look at an Established Topic in Xenotransplantation
Collaboration between Dr Allan Kirk (Emory transplant surgeon) and RBC leadership led to Emory receiving 2 million in grant research for the use of GAL-ko pigs. UGA and Emory will investigate new iPSC cell technology using these pigs. The present funded grant furthers Emory’s pre-clinical studies to refine NPI xenotransplantation into a strategy facilitating a first human trial.
Toxicology Journal Published a Significant Advance of the RBC: Metabolomics and Human Stem Cells Improve Developmental Toxicology Assays
The new testing model fills a void left by current methods and provides human-specific results. We identified major pathways affected by steroid hormones in GLCs, which demonstrated that the developed methodology can be used to investigate the potential impacts and comparative response of selected environmentally relevant EACs in human stem cells.
The overarching objective is to determine endocrine active compounds (EACs) adverse outcome pathway relationships. The methods used by the Regenerative Bioscience Center will expand the number of chemicals that can be tested each year, reducing process time, effort and cost while also minimizing animal use."By better predicting whether chemicals have the potential to impact health and human development, these grants will not only advance the science necessary to improve chemical safety but protect the well-being and futures of children in this nation," said Lek Kadeli of the EPA's Office of Research and Development.
A Porcine Stroke Model for Neurological Repair
Only study in the entire USA to develop and characterize a novel pig middle cerebral artery occlusion (MCAO) ischemic stroke model. Efforts to develop stroke treatments have met with limited success despite an intense need to produce novel treatments. These results suggest that the pig model is potentially a robust system for the study of stroke pathophysiology and potential diagnostics and therapeutics.
UGA-RBC joins NIIMBL
The University of Georgia is partnering in a biopharmaceutical innovation institute that aims to boost market production of cell-based therapies and develop a skilled workforce trained for the biotechnology and pharmaceutical industry. The new public-private partnership, called the National Institute for Innovation of Manufacturing Biopharmaceuticals, or NIIMBL represents a total investment of $250 million, including $129 million in private cost-share commitments.
Georgia Research Alliance Eminent Scholar. Professor
Associate Professor Regenerative Medicine
Associate Professor Veterinary Medicine
Regenerative Medicine and Stem Cell Therapies
Realizing the Extraordinary Promise of Regenerative Medicine Research
Known by its acronym RBC — The Regenerative Bioscience Center links researchers and resources collaborating in a wide range of disciplines to develop new cures for the devastating diseases that touch all of our lives. With its potential restorative powers, regenerative medicine could offer new ways of treating diseases for which there are currently no treatments - including heart disease, Parkinson's, Alzheimer’s and stroke.
"The RBC provides a base where it brings together devoted researchers and holds the infrastructure necessary to support and energize these collaborations, says Steven Stice Director of the RBC. There's nothing that excites me more than the promise and hope of stem cell therapy."
In many cases, individual members of the institute have been awarded research grants from both public, government and private sources of funding. Among the public supporters has been the National Institutes of Health and The American Heart Institute. Gov’t agencies include; Environmental Protection Agency (EPA) and Department of Defense (DOD). A strong private supporter has been the Bill and Melinda Gates Foundation, which contributed $1.5 Million to develop naturally disease resistance chickens to help poor third world families increase their standard of living.
The RBC promotes cross-discipline and multi-institutional research within the Georgia Research Alliance with the Georgia Institute of Technology, Georgia State, the Medical College of Georgia, and Emory University. The center increases knowledge, facility, and technology resources to gain external funding.
In addition to research, the RBC provides education to national and international researchers, graduate and undergraduate classes taught by the faculty, and a Young Scholar program for high school students interested in biomedical science careers. "As a group we inspire each other; researchers, students and outside constituent teams through a shared vision for the future and how regenerative bioscience (repair, discovery and safety) research will improve the quality of life for all ages,"claims Stice.