Samuel P. Franklin

Samuel P. Franklin

RBC
  • Assistant Professor, Orthopedics

  • Diplomate of the American College of Veterinary Sports Medicine & Rehabilitation (2013)
  • Diplomate of the American College of Veterinary Surgeons (2012)
  • PhD in Veterinary Pathobiology, University of Missouri (2012)
  • Small Animal Surgery Residency, University of Missouri (2008-2012)
  • Rotating Internship in Small Animal Medicine and Surgery, University of Pennsylvania (2007-2008)
  • Doctor of Veterinary Medicine, Colorado State University (2007)
  • Master of Science, University of Maryland (2004)

Dr. Franklin’s research and clinical interests overlap considerably. He is particularly interested in evaluating regenerative therapies and tissue engineering strategies for treatment of cartilage injury and osteoarthritis. As a result, he investigates use of biological therapies such as platelet rich plasma (PRP), mesenchymal stem cells (MSCs), and stromal vascular fraction (SVF), as well as use of biodegradable scaffolding materials for treating these conditions. Clinically, Dr. Franklin is focused on minimally invasive orthopedic techniques such as arthroscopy and sports medicine treatments including, but not limited to, PRP and cellular therapies. Lastly, Dr. Franklin is interested in assessing and optimizing the use of MRI and ultrasound for assessing musculoskeletal structures in dog for both for clinical and research purposes.

Dr. Franklin’s research interests include:

  • Regenerative medicine therapies for treating cartilage injury and osteoarthritis including, but not limited to:
    • Use of biodegradable, biocompatible constructs in conjunction with cellular therapies (stem cells, platelet rich plasma, stromal vascular fraction) for creating osteochondral constructs to treat focal osteochondral defects
    • Use of intra-articular biological therapies such as platelet rich plasma (PRP), mesenchymal stem cells (MSCs), and stromal vascular fraction (SVF) for improving cartilage health, lameness, and function
    • Use of osteochondral allografting for treating focal osteochondral defects
    • Numerous biological therapies (PRP, MSCs, SVF) to augment other treatments for osteoarthritis and cartilage injury
  • Regenerative medicine therapies for enhancing osseous union:
    • Current focus is being directed toward the utility of PRP in enhancing osseous union
    • Future work with RBC collaborators will potentially involve assessments of MSCs in improving bone healing
    • Non-invasive imaging modalities:
      • Particular attention is being directed toward developing MRI and ultrasound protocols for assessment of canine musculoskeletal structures including:
        • Quantitative MRI for assessing cartilage health in both knees and elbows in dogs
        • MRI for assessing meniscal damage in dogs
        • Ultrasound for assessing meniscal damage in dogs
        • MRI for assessing osseous healing in dogs
        • Ultrasound for assessing osseous healing in dogs

    Dr. Franklin’s clinical areas of expertise and interest include:

    • Minimally invasive orthopedic procedures and sports medicine
      • Arthroscopy is Dr. Franklin’s most well developed and preferred clinical technique for performing orthopedic treatment of patients
      • Commonly used sports medicine therapies include PRP, occasionally SVF, and other ‘sports medicine treatments’ including extra-corporeal shockwave therapy, physical rehabilitation, and others
    • Minimally invasive imaging of musculoskeletal structures including MRI and ultrasound

Recently completed or ongoing projects:

  • ​Characterization of canine platelet rich plasmas
  • Validation of ELISAs for characterizing growth factor profiles of canine PRPs
  • Efficacy of PRP and stromal vascular fraction combined with a novel nanofiber polymer for treatment of osteochondral defects in dogs
  • Efficacy of PRP in hastening osseous union in a high tibial osteotomy model in dogs
  • Comparison of ultrasound, MRI, and arthroscopy for diagnosing meniscal pathology in dogs
  • Comparison of MRI and arthroscopy for characterizing articular cartilage and subchondral bone pathology in dogs with elbow dysplasia

Relevant Resources

  • Faculty profile​VIEW
  • ​Email Sam Franklin
  • ​Sam P. Franklin DVM, MS, PhD, Diplomate, American College of Veterinary Surgeons Diplomate, American College of Veterinary Sports Medicine & Rehabilitation, Assistant Professor, Small Animal Orthopedic Surgery

Selected Publications

  • ​Publications by Dr. Franklin may be found at PubMed.