We are developing and applying Omics-based systems-level approaches, including metabolomics, proteomics and lipidomics, to investigate the biological consequences of environmental exposure and human disease at the molecular level. A large inventory of altered biomolecules revealed by Omics would provide key insights into the metabolic and other signaling pathways associated with exposure/disease and yield an unprecedented boon of molecular information critical to understanding responses at both the individual and population level.
Microbiome has a profound effect on human health through its key role in a wide range of host-related functions, ranging from metabolic processing to immune cell development. Accumulating evidence has indicated that dysregulated microbiome contributes in a significant way to a variety of human diseases. We are developing an integrated biology approach to characterize and understand the complex interactions between the microbiome community and environmental exposure, as well as human disease.... ►Read More
- Environmental Omics
- Metabolomics and Lipidomics
- Molecular Toxicology
- Biomarker Discovery
- DNA and Protein Damage
- Oxidative Stress
- Risk Assessment
- Mass Spectrometry (GC-MS and LC-MS)
- Triple quadrupole mass spectrometer (QQQ)
- Quantitation of Adducts, Metabolites, Peptides and Lipids
- Gut Microbiome
- Publications by Kun Lu may be found at PubMed.